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A vaccine is a biological preparation that provides active acquired immunity to a particular disease.A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins.Stimulating immune responses with an infectious agent is known as immunization.Vaccination includes various ways of administering immunogens.widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world.The terms vaccine and vaccination are derived from Variolae vaccinae (smallpox of the cow), the term devised by Edward Jenner to denote cowpox.

Generically, the process of artificial induction of immunity, in an effort to protect against infectious disease, works by 'priming' the immune system with an 'immunogen'.Sometimes, protection fails because the host's immune system simply does not respond adequately or at all.Lack of response commonly results from clinical factors such as diabetes, steroid use, HIV infection or age.The first rabies immunization was given by Louis Pasteur to a child after he was bitten by a rabid dog.Since then, it has been found that, in people with healthy immune systems, four doses of rabies vaccine over 14 days, wound care, and treatment of the bite with rabies immune globulin, commenced as soon as possible after exposure, is effective in preventing rabies in humans.

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